Endocrine Abstracts

Since its first description as a phosphaturic agent in the early 2000s, the Fibroblast Growth Factor 23 (FGF23) has rapidly become the third key player of phosphate/calcium metabolism with the two ‘old’ PTH and vitamin D.FGF23 is a protein synthesized by osteocytes that has three main effects: hypophosphatemia (through an inhibition of phosphate reabsorption in the proximal tubule), decreased PTH levels and decreased 1–25 OH2 le...

Background: Klinefelter Syndrome (KS) patients, defined by a 47 XXY karyotype, suffer from osteoporosis, with an increased risk of mortality after femoral neck fracture. The mechanisms underlying this bone alteration remain unclear.Patients and methods: In KS patients naïve from testosterone substitution therapy (TST), we assessed bone microarchitecture at distal radius and tibia by High Resolution peripheral Computed Quantitative Tomography, and bo...